Flood has disastrous effects on the lives of all human beings and considered as a curse especially for women with disabilities because they face greater challenges for their survival. The objective of the study was to investigate the socio-economic vulnerabilities faced by the women with disability during flood in Muzzafargarh. Responses were collected through two focus group discussions. Acquired responses of FGDs were analyzed through thematic analysis. In the focus group discussion six themes were selected (i) Knowledge and faith about flood (ii) Social issues of disabled women and social isolation (iii) Economic Problems of disabled women (iv) Receiving help pre-flood (v) Receiving help post-Flood (vi) Suggestions to overcome the issues in future. The study reported that the majority of the respondents strongly believed that no one could control floods because it is natural and the will of Allah (God) but some of the respondents stated that India, feudal lords, and negligence of management are responsible for flood in Pakistan. study recommended that Government should have to do planning to control flood, they have to make new dams to save the water”. The state should have to fulfill the basic necessities of life of the flood-affected people. Government should establish special schools, scholarship and jobs for the disabled people.