Minorities are basically defined as ascribed status such as gender, race, ethnic, and religious background. The objectives of the current study were to determine the issues of religious minorities in Southern Punjab; to know the minorities’ social condition and to examine the government role regarding the protection of minorities. The study was conducted in two districts Rahim Yar khan and Multan of Southern Punjab, Pakistan. Data were collected from 200 minority residents of districts Rahim Yar Khan and Multan through structured interview schedule. Data were collected through purposive sampling technique. Collected data were analyzed by using Statistical Package for Social Science (SPSS) 23.0 version. Data descriptive and inferential was analyzed included frequency, percentage, standard deviation. It was found that majority 121 (60.5) of the respondents did not have the property; majority 162 (81.0) of the respondents said that they cannot openly perform their worship; majority 152 (76.0) of the respondents said that government is not serious in resolving their issues; majority 183 (91.5) of the respondents were agreed that they did not face discrimination in medical care; majority 183 (91.5) of the respondents feel comfortable during travelling; majority 120 (60.0) of the respondent did agree that they did not face work place discrimination; majority 106(53.0) of the respondents said that they face obstacle to get admission in the school/collage/university; majority 149 (74.5) of the respondents were not the member of any political party. It is suggested that government of Pakistan should have to protect the rights of minorities in the light of the speeches of Quaid-e-Azam. The responsible institutions should ensure the implementation of the previous laws that guaranteed the safety of the minorities and make the new laws where needed to tackle the issues of subjugation of minorities.